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KMID : 0385219930030020109
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Korean Journal of Gerontology
1993 Volume.3 No. 2 p.109 ~ p.115
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Effect of Reed Root Extract on Physiological Activity of Rats
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Choi Jin-Ho
Kim Il-Sung
Kim Jae-Il
Kim Dong-Woo
Yoon Tae-Heon
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Abstract
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Sprague-Dawley(SD) male rats were fed high cholesterol diet, and also were orally administered with 0, 25, 50, 100 and ㎎/㎏ BW of reed root extract(RRE: Phragmites communis) for 4 weeks. Effect of reed root extract on body weight gain, feed and gross efficiencies, changes in triglyceride and cholesterol levels, formations of hydroxyl radical and lipid peroxide, changes in LDL and HDL cholesterol levels and atherogenic index, and superoxide dismutase activity in serum of rats were evaluated. Body weight gain, feed and gross efficiencies were slightly increased by administration of RRE compared with control group(RRE-0), but there were no significant differences in administered groups of RRE. Administrations of RRE resulted in a marked decreases in serum triglyceride(40∼60%) cholesterol (15∼20%), but HDL cholesterol levels were ㎎/dl to 55.9±8.6∼48.2±4.8㎎/dl by administration of RRE(10∼20%), but HDL cholesterol levels were no significant differences in administered groups of RRE. Administrations of RRE resulted in a marked increase in ratio of HDL cholesterol/total cholesterol(25∼20%), atherogenic index(25∼60%) compared with control group(p<0.05∼0.001). Formations of hydroxyl radical and malondialdehyde significantly decreased in ranges of 5∼25% and 15∼20%, respectively by administration of RRE, and superoxide dismutase activity slightly increased by administration of RRE(p<0.05∼0.01). The effect of reed root extract may be due to inhibition of lipid peroxidation with less formation of hydroxyl radical and a larger activity of superoxide dismutase, resulting in a greater decreases in a synthesis of triglyceride, total cholesterol and LDL cholesterol, and in an atherogenic index.
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KEYWORD
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reed root, triglyceride, cholesterol, LDL and HDL cholesterol, atherogenic index, hydroxyl radical, superoxide dismutase(SOD), malondialdehyde(MDA)
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